HORDB

ID: hor002531
Uniprot ID: A0A0C6E0T9
Protein name: Thais excitatory peptide-1
Gene name: NA
Organism: Reishia clavigera (Sea snail) (Purpura clavigera)
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Reishia (genus), Muricidae (family), Muricoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: KCSGKWAIHACWGGN
Length: 15(29-43)
Propeptide: MTTRGSCVMCAAMMSLLILSSIVSNAEGKCSGKWAIHACWGGNGKRSGIPAEEDDNTAKSLDLLRRLLRRKVSSSPYLPSLEDTVYVPVQPEDFLSSSESLPSSLSSSSSLLSSSSPFEDGFSEDVEEAEAAAASFVPSKNRLASLTTILRKLQQGRDDFQ
Signal peptide: MTTRGSCVMCAAMMSLLILSSIVSNAEG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Be involved in the contraction of the digestive and reproductive systems
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002531_AF2.pdb

hor002531_ESM.pdb

Mass:	186778	Formula:	C71H104N22O18S2
Absent amino acids:	DEFLMPQRTVY	Common amino acids:	G
pI:	8.82	Basic residues:	3
Polar residues:	7	Hydrophobic residues:	5
Hydrophobicity:	-34.67	Boman Index:	-722
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	39.33
Instability Index:	4261.33	Extinction Coefficient cystines:	11125
Absorbance 280nm:	794.64

PubMed ID: 16309789
Title: Novel Excitatory Neuropeptides Isolated From a Prosobranch Gastropod, Thais Clavigera: The Molluscan Counterpart of the Annelidan GGNG Peptides